ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kinase activity controls the formation of ROCK2/STAT3/JAK2 com...

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Detalles Bibliográficos
Autores principales: Chen, Wei, Nyuydzefe, Melanie S., Weiss, Jonathan M., Zhang, Jingya, Waksal, Samuel D., Zanin-Zhorov, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226480/
https://www.ncbi.nlm.nih.gov/pubmed/30413785
http://dx.doi.org/10.1038/s41598-018-35109-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226480/
https://www.ncbi.nlm.nih.gov/pubmed/30413785
http://dx.doi.org/10.1038/s41598-018-35109-9

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