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Transition path times of coupled folding and binding reveal the formation of an encounter complex

The association of biomolecules is the elementary event of communication in biology. Most mechanistic information of how the interactions between binding partners form or break is, however, hidden in the transition paths, the very short parts of the molecular trajectories from the encounter of the t...

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Detalles Bibliográficos
Autores principales: Sturzenegger, Flurin, Zosel, Franziska, Holmstrom, Erik D., Buholzer, Karin J., Makarov, Dmitrii E., Nettels, Daniel, Schuler, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226497/
https://www.ncbi.nlm.nih.gov/pubmed/30413694
http://dx.doi.org/10.1038/s41467-018-07043-x