Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases

In silico quantification of cell proportions from mixed-cell transcriptomics data (deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize that matrices created using only healthy samples from a single microarray platform would introduce biological and technical bi...

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Detalles Bibliográficos
Autores principales: Vallania, Francesco, Tam, Andrew, Lofgren, Shane, Schaffert, Steven, Azad, Tej D., Bongen, Erika, Haynes, Winston, Alsup, Meia, Alonso, Michael, Davis, Mark, Engleman, Edgar, Khatri, Purvesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226523/
https://www.ncbi.nlm.nih.gov/pubmed/30413720
http://dx.doi.org/10.1038/s41467-018-07242-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226523/
https://www.ncbi.nlm.nih.gov/pubmed/30413720
http://dx.doi.org/10.1038/s41467-018-07242-6

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