Cargando…

Age stratification corrects bias in estimated hazard of APOE genotype for Alzheimer's disease

INTRODUCTION: The apolipoprotein E (APOE) e4 allele is a major genetic risk factor of late-onset Alzheimer's disease. However, its interaction with two other canonical risk factors, age and sex, is not clear. Previous studies have reported conflicting results on its differential effects in men...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Li, Caselli, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226550/ https://www.ncbi.nlm.nih.gov/pubmed/30450407 http://dx.doi.org/10.1016/j.trci.2018.09.006

Ejemplares similares

APOE and dementia – resequencing and genotyping in 105,597 individuals
por: Rasmussen, Katrine L., et al.
Publicado: (2020)

The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease
por: Jia, Longfei, et al.
Publicado: (2020)

Beyond the Fire-Hazard Mentality of Medicine: The Ecology of Infectious Diseases
por: Bradbury, Jane
Publicado: (2003)

Publisher Correction: Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes
por: Schramm, Catherine, et al.
Publicado: (2022)

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
por: Jun, Gyungah R., et al.
Publicado: (2022)

Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise
por: Jensen, Camilla Steen, et al.
Publicado: (2019)

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies
por: Wang, Tingting, et al.
Publicado: (2022)

Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes
por: Schramm, Catherine, et al.
Publicado: (2022)

Alzheimer's Prevention Initiative Generation Program: Development of an APOE genetic counseling and disclosure process in the context of clinical trials
por: Langlois, Carolyn M., et al.
Publicado: (2019)

Correcting the bias against interdisciplinary research
por: Shapiro, Ehud
Publicado: (2014)

APOE genotype and Alzheimer’s immunotherapy
por: Pankiewicz, Joanna E., et al.
Publicado: (2017)

Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants
por: Prokopenko, Inga, et al.
Publicado: (2019)

Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease
por: Mishra, Aarti, et al.
Publicado: (2018)

APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
por: Belloy, Michael E., et al.
Publicado: (2023)

Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment
por: Wang, Guoqiao, et al.
Publicado: (2015)

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
por: Fernández-Calle, Rosalía, et al.
Publicado: (2022)

Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status
por: Wu, Che‐Yuan, et al.
Publicado: (2020)

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
por: Ghisays, Valentina, et al.
Publicado: (2020)

Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
por: Audrain, Mickael, et al.
Publicado: (2020)

Dairy cows: in the age of the genotype, #phenotypeisking
por: Coffey, Mike
Publicado: (2020)

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice
por: Balu, Deebika, et al.
Publicado: (2023)

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
por: Jones, Nahdia S., et al.
Publicado: (2018)

The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease
por: Löwe, Luise Christine, et al.
Publicado: (2016)

Development of Written Materials for Participants in an Alzheimer's Disease and Related Dementias Screening Trial
por: Head, Katharine J, et al.
Publicado: (2022)

Analyses of natural courses of Japanese patients with Alzheimer's disease using placebo data from placebo-controlled, randomized clinical trials: Japanese Study on the Estimation of Clinical course of Alzheimer's disease
por: Watanabe, Mitsunori, et al.
Publicado: (2019)

A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimer’s disease onset
por: Hane, Francis, et al.
Publicado: (2018)

Characterization of APOE and TOMM40 allele frequencies in the Japanese population
por: Nishimura, Akira, et al.
Publicado: (2017)

Philosophical bias is the one bias that science cannot avoid
por: Andersen, Fredrik, et al.
Publicado: (2019)

Biased proportional hazard regression estimator in the existence of collinearity
por: Sirohi, Anu, et al.
Publicado: (2023)

The National Institute on Aging Late‐Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery
por: Reyes‐Dumeyer, Dolly, et al.
Publicado: (2022)

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease
por: Yassine, Hussein N., et al.
Publicado: (2016)

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease
por: Qian, Jing, et al.
Publicado: (2021)

High-Density Lipoprotein Changes in Alzheimer’s Disease Are APOE Genotype-Specific
por: Hong, Brian V., et al.
Publicado: (2022)

Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event‐based model of disease progression
por: Firth, Nicholas C., et al.
Publicado: (2020)

APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)
por: Granot‐Hershkovitz, Einat, et al.
Publicado: (2020)

Interplay Between Microglia and Alzheimer’s Disease—Focus on the Most Relevant Risks: APOE Genotype, Sex and Age
por: Chen, Yanting, et al.
Publicado: (2021)

APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains
por: Ojo, Joseph O., et al.
Publicado: (2021)

Age and sex differences in the association between APOE genotype and Alzheimer’s disease in a Taiwan Chinese population
por: Huang, Ling-Chun, et al.
Publicado: (2023)

Rooting out bias
por: Kuehn, Bridget M
Publicado: (2017)

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age
por: Eren, Erden, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_59rijt4ggd2b6addiu35uguukc