A novel disulfide bond-mediated cleavable RGD-modified PAMAM nanocomplex containing nuclear localization signal HMGB1 for enhancing gene transfection efficiency

BACKGROUND: Polyamidoamine (PAMAM) dendrimers modified by polyethylene glycol (PEG) have frequently been investigated as a delivery carrier for gene therapy. However, modification of PAMAM with PEG using covalent linkage significantly reduces the cellular uptake rate and the transfection efficiency....

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Detalles Bibliográficos
Autores principales: Li, Ji, Han, Yuting, Lu, Yue, Song, Baohui, Zhao, Ming, Hu, Haiyang, Chen, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228086/
https://www.ncbi.nlm.nih.gov/pubmed/30464464
http://dx.doi.org/10.2147/IJN.S182445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228086/
https://www.ncbi.nlm.nih.gov/pubmed/30464464
http://dx.doi.org/10.2147/IJN.S182445

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