The Impact of ESCRT on Aβ(1-42) Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease

Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ(42) toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash the full Aβ(42) toxic potential. Consistent wi...

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Detalles Bibliográficos
Autores principales: Fruhmann, Gernot, Marchal, Christelle, Vignaud, Hélène, Verduyckt, Mathias, Talarek, Nicolas, De Virgilio, Claudio, Winderickx, Joris, Cullin, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230623/
https://www.ncbi.nlm.nih.gov/pubmed/30455629
http://dx.doi.org/10.3389/fnmol.2018.00406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230623/
https://www.ncbi.nlm.nih.gov/pubmed/30455629
http://dx.doi.org/10.3389/fnmol.2018.00406

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