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The Impact of ESCRT on Aβ(1-42) Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease
Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ(42) toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash the full Aβ(42) toxic potential. Consistent wi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230623/ https://www.ncbi.nlm.nih.gov/pubmed/30455629 http://dx.doi.org/10.3389/fnmol.2018.00406 |