Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice

The haemagglutinin (HA) of H1N1 and H3N2 influenza A virus (IAV) subtypes has to be activated by host proteases. Previous studies showed that H1N1 virus cannot replicate efficiently in Tmprss2(−/−) knock-out mice whereas H3N2 viruses are able to replicate to the same levels in Tmprss2(−/−) as in wil...

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Detalles Bibliográficos
Autores principales: Lambertz, Ruth L. O., Pippel, Jan, Gerhauser, Ingo, Kollmus, Heike, Anhlan, Darisuren, Hrincius, Eike R., Krausze, Joern, Kühn, Nora, Schughart, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230768/
https://www.ncbi.nlm.nih.gov/pubmed/30084768
http://dx.doi.org/10.1099/jgv.0.001128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230768/
https://www.ncbi.nlm.nih.gov/pubmed/30084768
http://dx.doi.org/10.1099/jgv.0.001128

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