The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel

Ubiquitin-specific protease 15 (USP15) regulates important cellular processes, including transforming growth factor β (TGF-β) signaling, mitophagy, mRNA processing, and innate immune responses; however, structural information on USP15's catalytic domain is currently unavailable. Here, we determ...

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Detalles Bibliográficos
Autores principales: Ward, Stephanie J., Gratton, Hayley E., Indrayudha, Peni, Michavila, Camille, Mukhopadhyay, Rishov, Maurer, Sigrun K., Caulton, Simon G., Emsley, Jonas, Dreveny, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231127/
https://www.ncbi.nlm.nih.gov/pubmed/30228188
http://dx.doi.org/10.1074/jbc.RA118.003857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231127/
https://www.ncbi.nlm.nih.gov/pubmed/30228188
http://dx.doi.org/10.1074/jbc.RA118.003857

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