In vitro and in vivo quantification of chloroprocaine release from an implantable device in a piglet postoperative pain model

BACKGROUND: The pharmacokinetic properties and clinical advantages of the local anesthetic chloroprocaine are well known. Here, we studied the pharmacokinetic profile of a new hydrogel device loaded with chloroprocaine to investigate the potential advantages of this new strategy for postoperative pa...

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Detalles Bibliográficos
Autores principales: De Gregori, Simona, De Gregori, Manuela, Bloise, Nora, Bugada, Dario, Molinaro, Mariadelfina, Filisetti, Claudia, Allegri, Massimo, Schatman, Michael E, Cobianchi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231440/
https://www.ncbi.nlm.nih.gov/pubmed/30510443
http://dx.doi.org/10.2147/JPR.S180163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231440/
https://www.ncbi.nlm.nih.gov/pubmed/30510443
http://dx.doi.org/10.2147/JPR.S180163

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