Regulating transcriptional activity by phosphorylation: A new mechanism for the ARX homeodomain transcription factor

Aristaless-related homeobox (ARX) gene encodes a paired-type homeodomain transcription factor with critical roles in development. Here we identify that ARX protein is phosphorylated. Using mass spectrometry and in vitro kinase assays we identify phosphorylation at serines 37, 67 and 174. Through yea...

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Detalles Bibliográficos
Autores principales: Mattiske, Tessa, Tan, May H., Dearsley, Oliver, Cloosterman, Desiree, Hii, Charles S., Gécz, Jozef, Shoubridge, Cheryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231642/
https://www.ncbi.nlm.nih.gov/pubmed/30419043
http://dx.doi.org/10.1371/journal.pone.0206914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231642/
https://www.ncbi.nlm.nih.gov/pubmed/30419043
http://dx.doi.org/10.1371/journal.pone.0206914

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