Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA syn...

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Detalles Bibliográficos
Autores principales: Chim, Nicholas, Jackson, Lynnette N, Trinh, Anh M, Chaput, John C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231770/
https://www.ncbi.nlm.nih.gov/pubmed/30338759
http://dx.doi.org/10.7554/eLife.40444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231770/
https://www.ncbi.nlm.nih.gov/pubmed/30338759
http://dx.doi.org/10.7554/eLife.40444

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