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Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity
Inositol polyphosphate multikinase (IPMK) is a member of the IPK-superfamily of kinases, catalyzing phosphorylation of several soluble inositols and the signaling phospholipid PI(4,5)P(2) (PIP(2)). IPMK also has critical non-catalytic roles in p53, mTOR/Raptor, TRAF6 and AMPK signaling mediated part...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232094/ https://www.ncbi.nlm.nih.gov/pubmed/30420721 http://dx.doi.org/10.1038/s41598-018-34941-3 |