Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors

Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABA(A)Rs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsa...

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Detalles Bibliográficos
Autores principales: Nicholson, Martin W., Sweeney, Aaron, Pekle, Eva, Alam, Sabina, Ali, Afia B., Duchen, Michael, Jovanovic, Jasmina N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232101/
https://www.ncbi.nlm.nih.gov/pubmed/29904150
http://dx.doi.org/10.1038/s41380-018-0100-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232101/
https://www.ncbi.nlm.nih.gov/pubmed/29904150
http://dx.doi.org/10.1038/s41380-018-0100-y

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