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Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca(2+)/calcineurin signalling downstream of GABAA receptors
Benzodiazepines facilitate the inhibitory actions of GABA by binding to γ-aminobutyric acid type A receptors (GABA(A)Rs), GABA-gated chloride/bicarbonate channels, which are the key mediators of transmission at inhibitory synapses in the brain. This activity underpins potent anxiolytic, anticonvulsa...
Autores principales: | Nicholson, Martin W., Sweeney, Aaron, Pekle, Eva, Alam, Sabina, Ali, Afia B., Duchen, Michael, Jovanovic, Jasmina N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232101/ https://www.ncbi.nlm.nih.gov/pubmed/29904150 http://dx.doi.org/10.1038/s41380-018-0100-y |
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