Cargando…

Human adipose glycerol flux is regulated by a pH gate in AQP10

Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gotfryd, Kamil, Mósca, Andreia Filipa, Missel, Julie Winkel, Truelsen, Sigurd Friis, Wang, Kaituo, Spulber, Mariana, Krabbe, Simon, Hélix-Nielsen, Claus, Laforenza, Umberto, Soveral, Graça, Pedersen, Per Amstrup, Gourdon, Pontus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232157/ https://www.ncbi.nlm.nih.gov/pubmed/30420639 http://dx.doi.org/10.1038/s41467-018-07176-z

Ejemplares similares

Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization
por: Bjørkskov, Frederik Bühring, et al.
Publicado: (2017)

Purification of Functional Human TRP Channels Recombinantly Produced in Yeast
por: Zhang, Liying, et al.
Publicado: (2019)

Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization
por: Becares, Eva Ramos, et al.
Publicado: (2021)

Structure of the human ClC-1 chloride channel
por: Wang, Kaituo, et al.
Publicado: (2019)

The rapid “teabag” method for high-end purification of membrane proteins
por: Hering, Jenny, et al.
Publicado: (2020)

Isolation and Crystallization of the D156C Form of Optogenetic ChR2
por: Zhang, Liying, et al.
Publicado: (2022)

Cyclohexyl-α maltoside as a highly efficient tool for membrane protein studies
por: Missel, Julie Winkel, et al.
Publicado: (2021)

PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
por: Li, Ping, et al.
Publicado: (2022)

Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration
por: Rodrigues, Claudia, et al.
Publicado: (2019)

Structure and transport mechanism of P5B-ATPases
por: Li, Ping, et al.
Publicado: (2021)

Cryo-EM structure of the trehalose monomycolate transporter, MmpL3, reconstituted into peptidiscs
por: Couston, Julie, et al.
Publicado: (2023)

AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells
por: Mlinarić, Monika, et al.
Publicado: (2023)

Biophysical Assessment of Human Aquaporin-7 as a Water and Glycerol Channel in 3T3-L1 Adipocytes
por: Madeira, Ana, et al.
Publicado: (2013)

Rat Aquaporin-5 Is pH-Gated Induced by Phosphorylation and Is Implicated in Oxidative Stress
por: Rodrigues, Claudia, et al.
Publicado: (2016)

Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing
por: Martinotti, Simona, et al.
Publicado: (2019)

Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup
por: Steffen, Jonas Hyld, et al.
Publicado: (2022)

Characterization of human aquaporin protein-protein interactions using microscale thermophoresis (MST)
por: Al-Jubair, Tamim, et al.
Publicado: (2022)

High-yield overproduction and purification of human aquaporins from Pichia pastoris
por: Al-Jubair, Tamim, et al.
Publicado: (2022)

Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins
por: Preisler, Sarah Spruce, et al.
Publicado: (2021)

Aquaglyceroporin AQP7's affinity for its substrate glycerol. Have we reached convergence in the computed values of glycerol-aquaglyceroporin affinity?
por: Falato, Michael, et al.
Publicado: (2022)

Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9
por: Bernardino, Raquel L., et al.
Publicado: (2018)

Aquaporin-10 Represents an Alternative Pathway for Glycerol Efflux from Human Adipocytes
por: Laforenza, Umberto, et al.
Publicado: (2013)

Cryo-EM structure supports a role of AQP7 as a junction protein
por: Huang, Peng, et al.
Publicado: (2023)

Microfluidic-Derived Detection of Protein-Facilitated Copper Flux Across Lipid Membranes
por: Górecki, Kamil, et al.
Publicado: (2022)

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease
por: Skjørringe, Tina, et al.
Publicado: (2017)

Separation of Peptides with Forward Osmosis Biomimetic Membranes
por: Bajraktari, Niada, et al.
Publicado: (2016)

Honey-Mediated Wound Healing: H(2)O(2) Entry through AQP3 Determines Extracellular Ca(2+) Influx
por: Martinotti, Simona, et al.
Publicado: (2019)

The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water
por: Noronha, Henrique, et al.
Publicado: (2016)

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
por: Gotfryd, Kamil, et al.
Publicado: (2020)

Immunohistochemical Localization of the Aquaporins AQP1, AQP3, AQP4, and AQP5 in the Mouse Respiratory System
por: Matsuzaki, Toshiyuki, et al.
Publicado: (2009)

Sweet Cherry (Prunus avium L.) PaPIP1;4 Is a Functional Aquaporin Upregulated by Pre-Harvest Calcium Treatments that Prevent Cracking
por: Breia, Richard, et al.
Publicado: (2020)

Structural basis of ion uptake in copper-transporting P(1B)-type ATPases
por: Salustros, Nina, et al.
Publicado: (2022)

Molecular Basis of Aquaporin-7 Permeability Regulation by pH
por: Mósca, Andreia F., et al.
Publicado: (2018)

Silencing of AQP3 induces apoptosis of gastric cancer cells via downregulation of glycerol intake and downstream inhibition of lipogenesis and autophagy
por: Chen, Liang, et al.
Publicado: (2017)

Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae
por: Bomholt, Julie, et al.
Publicado: (2013)

AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
por: Trillo-Contreras, José Luis, et al.
Publicado: (2019)

Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux
por: Khan, Liakot A., et al.
Publicado: (2013)

dDAVP Downregulates the AQP3-Mediated Glycerol Transport via V1aR in Human Colon HCT8 Cells
por: Centrone, Mariangela, et al.
Publicado: (2022)

The Aquaporin-3-Inhibiting Potential of Polyoxotungstates
por: Pimpão, Catarina, et al.
Publicado: (2020)

Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria
por: Li, Ping, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6jo7ltqdmtq2515126h4eb6s30