Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor

Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. In this study we discovered a new and unanticipated cyclosporine-dependent signaling pathway, with cycl...

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Detalles Bibliográficos
Autores principales: Groenendyk, Jody, Paskevicius, Tautvydas, Urra, Hery, Viricel, Clement, Wang, Kui, Barakat, Khaled, Hetz, Claudio, Kurgan, Lukasz, Agellon, Luis B., Michalak, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232179/
https://www.ncbi.nlm.nih.gov/pubmed/30420769
http://dx.doi.org/10.1038/s41598-018-34891-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232179/
https://www.ncbi.nlm.nih.gov/pubmed/30420769
http://dx.doi.org/10.1038/s41598-018-34891-w

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