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Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia
Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly remain an underrepresented population in pre-clinical cancer studies and clinical trials. The immune system plays a critical role in the effectiveness of many anti-cancer therapies in young hosts via tumor-sp...
Autores principales: | Duong, Lelinh, Radley-Crabb, Hannah G., Gardner, Joanne K., Tomay, Federica, Dye, Danielle E., Grounds, Miranda D., Pixley, Fiona J., Nelson, Delia J., Jackaman, Connie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232269/ https://www.ncbi.nlm.nih.gov/pubmed/30459812 http://dx.doi.org/10.3389/fgene.2018.00526 |
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