Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia

Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly remain an underrepresented population in pre-clinical cancer studies and clinical trials. The immune system plays a critical role in the effectiveness of many anti-cancer therapies in young hosts via tumor-sp...

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Detalles Bibliográficos
Autores principales: Duong, Lelinh, Radley-Crabb, Hannah G., Gardner, Joanne K., Tomay, Federica, Dye, Danielle E., Grounds, Miranda D., Pixley, Fiona J., Nelson, Delia J., Jackaman, Connie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232269/
https://www.ncbi.nlm.nih.gov/pubmed/30459812
http://dx.doi.org/10.3389/fgene.2018.00526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232269/
https://www.ncbi.nlm.nih.gov/pubmed/30459812
http://dx.doi.org/10.3389/fgene.2018.00526

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