Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase that mimics most of the metabolic responses to calorie restriction. Herein, we present an in silico analysis focusing on the molecular docking and dynamic simulation of t...

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Detalles Bibliográficos
Autores principales: Cuyàs, Elisabet, Verdura, Sara, Llorach-Parés, Laura, Fernández-Arroyo, Salvador, Joven, Jorge, Martin-Castillo, Begoña, Bosch-Barrera, Joaquim, Brunet, Joan, Nonell-Canals, Alfons, Sanchez-Martinez, Melchor, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232372/
https://www.ncbi.nlm.nih.gov/pubmed/30459716
http://dx.doi.org/10.3389/fendo.2018.00657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232372/
https://www.ncbi.nlm.nih.gov/pubmed/30459716
http://dx.doi.org/10.3389/fendo.2018.00657

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