Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s disease. Brain inflammation, microglia and astroglia...

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Detalles Bibliográficos
Autores principales: García-Domínguez, Irene, Veselá, Karolina, García-Revilla, Juan, Carrillo-Jiménez, Alejandro, Roca-Ceballos, María Angustias, Santiago, Marti, de Pablos, Rocío M., Venero, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232526/
https://www.ncbi.nlm.nih.gov/pubmed/30459561
http://dx.doi.org/10.3389/fncel.2018.00398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232526/
https://www.ncbi.nlm.nih.gov/pubmed/30459561
http://dx.doi.org/10.3389/fncel.2018.00398

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