Cargando…

Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic properties in diet-induced obese mice. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Mingxin, Zhang, Yemin, Cao, Yingkang, Zhang, Deling, Liu, Le, Guo, Yanghongyun, Wang, Changhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232724/ https://www.ncbi.nlm.nih.gov/pubmed/30459603 http://dx.doi.org/10.3389/fphar.2018.01180

Ejemplares similares

Retraction: Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes
Publicado: (2023)

PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes
por: Liu, Wei, et al.
Publicado: (2019)

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms
por: Panse, Madhura, et al.
Publicado: (2018)

APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells
por: Ding, Youming, et al.
Publicado: (2016)

5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes
por: Kwak, Hyun Jeong, et al.
Publicado: (2017)

Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes
por: Yang, Ming, et al.
Publicado: (2013)

Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation
por: Zou, Xiaomei, et al.
Publicado: (2020)

Cytoprotective Effect of Hispidin against Palmitate-Induced Lipotoxicity in C2C12 Myotubes
por: Park, Jun Myoung, et al.
Publicado: (2015)

Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum
por: Ye, Mao, et al.
Publicado: (2017)

Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-κB in C2C12 Myotubes
por: Zhao, Ming, et al.
Publicado: (2012)

ODP251 Thioredoxin-Interacting Protein (Txnip) And Cellular Senescence: Potential Adverse Effects of Txnip Deficiency.
por: Abubaker, Mohammed, et al.
Publicado: (2022)

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases
por: Yoshihara, Eiji, et al.
Publicado: (2014)

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases
por: Tsubaki, Haruka, et al.
Publicado: (2020)

Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition
por: Li, H.B., et al.
Publicado: (2015)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis
por: Zervou, Sevasti, et al.
Publicado: (2013)

Insulin‐stimulated Rac1‐GTP binding is not impaired by palmitate treatment in L6 myotubes
por: Stierwalt, Harrison D., et al.
Publicado: (2018)

Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress
por: Kim, Tae Jin, et al.
Publicado: (2022)

Activation of IGF-1 pathway and suppression of atrophy related genes are involved in Epimedium extract (icariin) promoted C2C12 myotube hypertrophy
por: Lin, Yi-An, et al.
Publicado: (2021)

Palmitate-induced ER stress and inhibition of protein synthesis in cultured myotubes does not require Toll-like receptor 4
por: Perry, Ben D., et al.
Publicado: (2018)

Docosahexaenoic acid counteracts palmitate‐induced endoplasmic reticulum stress in C2C12 myotubes: Impact on muscle atrophy
por: Woodworth‐Hobbs, Myra E., et al.
Publicado: (2017)

Pyrroloquinoline Quinone Modifies Lipid Profile, but Not Insulin Sensitivity, of Palmitic Acid-Treated L6 Myotubes
por: Supruniuk, Elżbieta, et al.
Publicado: (2020)

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer
por: Morrison, Jennifer A, et al.
Publicado: (2014)

A Class I Histone Deacetylase Inhibitor Attenuates Insulin Resistance and Inflammation in Palmitate-Treated C2C12 Myotubes and Muscle of HF/HFr Diet Mice
por: Lee, Soo Jin, et al.
Publicado: (2020)

Nitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization
por: Ogata, Fernando Toshio, et al.
Publicado: (2013)

In Vitro Palmitate Treatment of Myotubes from Postmenopausal Women Leads to Ceramide Accumulation, Inflammation and Affected Insulin Signaling
por: Abildgaard, Julie, et al.
Publicado: (2014)

Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus
por: Masutani, Hiroshi, et al.
Publicado: (2012)

PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
por: Chien, Hung-Che, et al.
Publicado: (2021)

Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes
por: Fu, Wen-Cheng, et al.
Publicado: (2021)

Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice
por: Liu, Min, et al.
Publicado: (2020)

Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation
por: Denes, Lance T., et al.
Publicado: (2019)

Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231
por: Turturro, Francesco, et al.
Publicado: (2007)

Pyropia yezoensis Protein Prevents Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes
por: Lee, Min-Kyeong, et al.
Publicado: (2018)

Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP)
por: Yang, Dejiang, et al.
Publicado: (2021)

Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes
por: Huang, Shujuan, et al.
Publicado: (2017)

Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans
por: Cai, Wai-Jiao, et al.
Publicado: (2011)

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway
por: Huang, Chunling, et al.
Publicado: (2016)

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
por: Zeng, Xin, et al.
Publicado: (2020)

Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes
por: Lee, Min-Kyeong, et al.
Publicado: (2019)

Dataset on the formation of Thioredoxin interacting protein (Txnip) containing redox sensitive high molecular weight nucleoprotein complexes
por: Hirata, Cristiane Lumi, et al.
Publicado: (2019)

iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
por: Cen, Haimei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hd0uv9tqa4cvgmracrtdf0v8gc