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Constricted migration increases DNA damage and independently represses cell cycle
Cell migration through dense tissues or small capillaries can elongate the nucleus and even damage it, and any impact on cell cycle has the potential to affect various processes including carcinogenesis. Here, nuclear rupture and DNA damage increase with constricted migration in different phases of...
Autores principales: | Pfeifer, Charlotte R., Xia, Yuntao, Zhu, Kuangzheng, Liu, Dazhen, Irianto, Jerome, García, Victor M. Morales, Millán, Leeza M. Santiago, Niese, Brandon, Harding, Shane, Deviri, Dan, Greenberg, Roger A., Discher, Dennis E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232975/ https://www.ncbi.nlm.nih.gov/pubmed/29742017 http://dx.doi.org/10.1091/mbc.E18-02-0079 |
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