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The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin

The in situ three-dimensional organization of chromatin at the nucleosome and oligonucleosome levels is unknown. Here we use cryo-electron tomography to determine the in situ structures of HeLa nucleosomes, which have canonical core structures and asymmetric, flexible linker DNA. Subtomogram remappi...

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Detalles Bibliográficos
Autores principales: Cai, Shujun, Böck, Désirée, Pilhofer, Martin, Gan, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233054/
https://www.ncbi.nlm.nih.gov/pubmed/30091658
http://dx.doi.org/10.1091/mbc.E18-05-0331