Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects

Neurodegenerative disorders, such as Huntington’s diseases and spinocerebellar ataxias (SCAs), are driven by proteins with expanded polyglutamine (polyQ) tracts. Recently, coiled-coil structures in polyQ regions of such proteins were shown to facilitate aggregate formation and ultimately lead to cel...

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Detalles Bibliográficos
Autores principales: Kwon, Min Jee, Han, Myeong Hoon, Bagley, Joshua A., Hyeon, Do Young, Ko, Byung Su, Lee, Yun Mi, Cha, In Jun, Kim, Seung Yeol, Kim, Dong Young, Kim, Ho Min, Hwang, Daehee, Lee, Sung Bae, Jan, Yuh Nung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233066/
https://www.ncbi.nlm.nih.gov/pubmed/30348793
http://dx.doi.org/10.1073/pnas.1807206115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233066/
https://www.ncbi.nlm.nih.gov/pubmed/30348793
http://dx.doi.org/10.1073/pnas.1807206115

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