A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes

Directed evolution is an important research activity in synthetic biology and biotechnology. Numerous reports describe the application of tedious mutation/screening cycles for the improvement of proteins. Recently, knowledge-based approaches have facilitated the prediction of protein properties and...

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Detalles Bibliográficos
Autores principales: Cadet, Frédéric, Fontaine, Nicolas, Li, Guangyue, Sanchis, Joaquin, Ng Fuk Chong, Matthieu, Pandjaitan, Rudy, Vetrivel, Iyanar, Offmann, Bernard, Reetz, Manfred T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233173/
https://www.ncbi.nlm.nih.gov/pubmed/30425279
http://dx.doi.org/10.1038/s41598-018-35033-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233173/
https://www.ncbi.nlm.nih.gov/pubmed/30425279
http://dx.doi.org/10.1038/s41598-018-35033-y

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