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AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans

AP endonuclease deficiency causes cell death and embryonic lethality in mammals. However, the physiological roles of AP endonucleases in multicellular organisms remain unclear, especially after embryogenesis. Here, we report novel physiological roles of the AP endonuclease EXO-3 from larval to adult...

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Detalles Bibliográficos
Autores principales: Miyaji, Masahiro, Hayashi, Yuichiro, Funakoshi, Masafumi, Tanaka, Akihiro, Zhang-Akiyama, Qiu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233223/
https://www.ncbi.nlm.nih.gov/pubmed/30425296
http://dx.doi.org/10.1038/s41598-018-35063-6