Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis

Glioblastoma multiforme (GBM) is one of the most hypoxic tumors of the central nervous system. Although temozolomide (TMZ) is an effective clinical agent in the GBM therapy, the hypoxic microenvironment remains a major barrier in glioma chemotherapy resistance, and the underlying mechanisms are poor...

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Detalles Bibliográficos
Autores principales: Ge, Xin, Pan, Min-Hong, Wang, Lin, Li, Wei, Jiang, Chengfei, He, Jun, Abouzid, Khaled, Liu, Ling-Zhi, Shi, Zhumei, Jiang, Bing-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233226/
https://www.ncbi.nlm.nih.gov/pubmed/30425242
http://dx.doi.org/10.1038/s41419-018-1176-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233226/
https://www.ncbi.nlm.nih.gov/pubmed/30425242
http://dx.doi.org/10.1038/s41419-018-1176-7

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