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Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies
BACKGROUND: Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergence of LZD...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233381/ https://www.ncbi.nlm.nih.gov/pubmed/30459957 http://dx.doi.org/10.1186/s40780-018-0123-1 |