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Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

BACKGROUND: Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergence of LZD...

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Detalles Bibliográficos
Autores principales:	Hashimoto, Satsuki, Honda, Kyoko, Fujita, Kohei, Miyachi, Yuka, Isoda, Kazuya, Misaka, Ko, Suga, Yukio, Kato, Satoshi, Tsuchiya, Hiroyuki, Kato, Yukio, Okajima, Masaki, Taniguchi, Takumi, Shimada, Tsutomu, Sai, Yoshimichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233381/ https://www.ncbi.nlm.nih.gov/pubmed/30459957 http://dx.doi.org/10.1186/s40780-018-0123-1

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