Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer...

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Detalles Bibliográficos
Autores principales: Rizk, Fatma H, Saadany, Amira A El, Dawood, Lamees, Elkaliny, Heba H, Sarhan, Naglaa I, Badawi, Rehab, Abd-Elsalam, Sherief
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233475/
https://www.ncbi.nlm.nih.gov/pubmed/30519070
http://dx.doi.org/10.2147/JIR.S178767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233475/
https://www.ncbi.nlm.nih.gov/pubmed/30519070
http://dx.doi.org/10.2147/JIR.S178767

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