VIPER: variability-preserving imputation for accurate gene expression recovery in single-cell RNA sequencing studies

We develop a method, VIPER, to impute the zero values in single-cell RNA sequencing studies to facilitate accurate transcriptome quantification at the single-cell level. VIPER is based on nonnegative sparse regression models and is capable of progressively inferring a sparse set of local neighborhoo...

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Detalles Bibliográficos
Autores principales: Chen, Mengjie, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233584/
https://www.ncbi.nlm.nih.gov/pubmed/30419955
http://dx.doi.org/10.1186/s13059-018-1575-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233584/
https://www.ncbi.nlm.nih.gov/pubmed/30419955
http://dx.doi.org/10.1186/s13059-018-1575-1

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