Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein Bid. Loss of full-length Bid results in apoptosis-i...

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Detalles Bibliográficos
Autores principales: Salisbury-Ruf, Christi T, Bertram, Clinton C, Vergeade, Aurelia, Lark, Daniel S, Shi, Qiong, Heberling, Marlene L, Fortune, Niki L, Okoye, G Donald, Jerome, W Gray, Wells, Quinn S, Fessel, Josh, Moslehi, Javid, Chen, Heidi, Roberts, L Jackson, Boutaud, Olivier, Gamazon, Eric R, Zinkel, Sandra S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234033/
https://www.ncbi.nlm.nih.gov/pubmed/30281024
http://dx.doi.org/10.7554/eLife.40907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234033/
https://www.ncbi.nlm.nih.gov/pubmed/30281024
http://dx.doi.org/10.7554/eLife.40907

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