Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells

Cancer stem cells (CSCs) exhibit tumorigenic potential and can generate resistance to chemotherapy and radiotherapy. A labeled ornithine decarboxylase (ODC, a rate-limiting enzyme involved in polyamine [PA] biosynthesis) degradation motif (degron) system allows visualization of a fraction of CSC-lik...

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Detalles Bibliográficos
Autores principales: Tamari, Keisuke, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Hayashi, Kazuhiko, Kawamoto, Koichi, Murai, Noriyuki, Matsufuji, Senya, Isohashi, Fumiaki, Satoh, Taroh, Goto, Noriko, Tanaka, Shinji, Doki, Yuichiro, Mori, Masaki, Ogawa, Kazuhiko, Ishii, Hideshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234213/
https://www.ncbi.nlm.nih.gov/pubmed/30455990
http://dx.doi.org/10.1038/s41420-018-0117-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234213/
https://www.ncbi.nlm.nih.gov/pubmed/30455990
http://dx.doi.org/10.1038/s41420-018-0117-7

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