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Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis

RPS27L (Ribosomal protein S27-like), an evolutionarily conserved ribosomal protein, is a p53 target and a physiological p53 regulator. We previously reported that Rps27l disruption enhanced lymphomagenesis in Trp53(+/)(−) mice by triggering genome instability and sensitized Trp53(+/)(−) mice to radi...

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Detalles Bibliográficos
Autores principales: Xiong, Xiufang, Liu, Xia, Li, Haomin, He, Hengqian, Sun, Yi, Zhao, Yongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234217/
https://www.ncbi.nlm.nih.gov/pubmed/30425236
http://dx.doi.org/10.1038/s41419-018-1168-7