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The role of loops B and C in determining the potentiation of GABA(A) receptors by midazolam
Many benzodiazepines are positive allosteric modulators (PAMs) of GABA(A) receptors that cause sedation, hypnosis, and anxiolysis. Benzodiazepines bind GABA(A) receptors at the extracellular interface of the α and γ subunits. Within the α subunit, the benzodiazepine binding site is defined by three...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234229/ https://www.ncbi.nlm.nih.gov/pubmed/30459951 http://dx.doi.org/10.1002/prp2.433 |