Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa

LAY SUMMARY: We probed the evolutionary robustness of two antivirulence drugs, gallium and flucytosine, targeting the iron-scavenging pyoverdine in the opportunistic pathogen Pseudomonas aeruginosa. Using an experimental evolution approach in human serum, we showed that antivirulence treatments are...

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Detalles Bibliográficos
Autores principales: Rezzoagli, Chiara, Wilson, David, Weigert, Michael, Wyder, Stefan, Kümmerli, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234326/
https://www.ncbi.nlm.nih.gov/pubmed/30455950
http://dx.doi.org/10.1093/emph/eoy026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234326/
https://www.ncbi.nlm.nih.gov/pubmed/30455950
http://dx.doi.org/10.1093/emph/eoy026

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