Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure

The effects of the nitroxyl donor BMS-986231 on hemodynamics, left ventricular (LV) function, and pro-arrhythmic potential were assessed using canine heart failure models. BMS-986231 significantly (p < 0.05) increased LV end-systolic elastance, pre-load-recruitable stroke work, ejection fraction,...

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Detalles Bibliográficos
Autores principales: Hartman, J. Craig, del Rio, Carlos L., Reardon, John E., Zhang, Kefei, Sabbah, Hani N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234500/
https://www.ncbi.nlm.nih.gov/pubmed/30456334
http://dx.doi.org/10.1016/j.jacbts.2018.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234500/
https://www.ncbi.nlm.nih.gov/pubmed/30456334
http://dx.doi.org/10.1016/j.jacbts.2018.07.003

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