Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation

Two major issues are involved in clinical atherosclerosis treatment. First, there are no significant clinical markers for early diagnosis of atherosclerosis. Second, the plaque will not regress once it initiates even if the risk factors are removed. In this paper, the research shows that the hyperme...

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Autores principales: Zhong, Wei, Li, Bo, Xu, Yao, Yang, Ping, Chen, Rui, Wang, Zhongqun, Shao, Chen, Song, Juan, Yan, Jinchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234615/
https://www.ncbi.nlm.nih.gov/pubmed/30456333
http://dx.doi.org/10.1016/j.jacbts.2018.06.004
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author Zhong, Wei
Li, Bo
Xu, Yao
Yang, Ping
Chen, Rui
Wang, Zhongqun
Shao, Chen
Song, Juan
Yan, Jinchuan
author_facet Zhong, Wei
Li, Bo
Xu, Yao
Yang, Ping
Chen, Rui
Wang, Zhongqun
Shao, Chen
Song, Juan
Yan, Jinchuan
author_sort Zhong, Wei
collection PubMed
description Two major issues are involved in clinical atherosclerosis treatment. First, there are no significant clinical markers for early diagnosis of atherosclerosis. Second, the plaque will not regress once it initiates even if the risk factors are removed. In this paper, the research shows that the hypermethylation level of the microRNA 145 (miR-145) promoter is related to a DNMT1 and TET2 dynamic imbalance. The reduction of miR-145 causes NLRP3 (nucleotide-binding oligomerization domain-like receptor protein 3) inflammasome activation through CD137/NFATc1 signaling. These findings could be a potential target for plaque regression in the future.
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spelling pubmed-62346152018-11-19 Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation Zhong, Wei Li, Bo Xu, Yao Yang, Ping Chen, Rui Wang, Zhongqun Shao, Chen Song, Juan Yan, Jinchuan JACC Basic Transl Sci PRECLINICAL RESEARCH Two major issues are involved in clinical atherosclerosis treatment. First, there are no significant clinical markers for early diagnosis of atherosclerosis. Second, the plaque will not regress once it initiates even if the risk factors are removed. In this paper, the research shows that the hypermethylation level of the microRNA 145 (miR-145) promoter is related to a DNMT1 and TET2 dynamic imbalance. The reduction of miR-145 causes NLRP3 (nucleotide-binding oligomerization domain-like receptor protein 3) inflammasome activation through CD137/NFATc1 signaling. These findings could be a potential target for plaque regression in the future. Elsevier 2018-09-19 /pmc/articles/PMC6234615/ /pubmed/30456333 http://dx.doi.org/10.1016/j.jacbts.2018.06.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Zhong, Wei
Li, Bo
Xu, Yao
Yang, Ping
Chen, Rui
Wang, Zhongqun
Shao, Chen
Song, Juan
Yan, Jinchuan
Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title_full Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title_fullStr Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title_full_unstemmed Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title_short Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation
title_sort hypermethylation of the micro-rna 145 promoter is the key regulator for nlrp3 inflammasome-induced activation and plaque formation
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234615/
https://www.ncbi.nlm.nih.gov/pubmed/30456333
http://dx.doi.org/10.1016/j.jacbts.2018.06.004
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