mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

N(6)-Methyladenosine (m(6)A) modification of messenger RNA (mRNA) is emerging as an important regulator of gene expression that impacts different developmental and biological processes, and altered m(6)A homeostasis is linked to cancer(1-5). m(6)A is catalyzed by METTL3 and enriched in the 3’ untran...

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Detalles Bibliográficos
Autores principales: Choe, Junho, Lin, Shuibin, Zhang, Wencai, Liu, Qi, Wang, Longfei, Ramirez-Moya, Julia, Du, Peng, Kim, Wantae, Tang, Shaojun, Sliz, Piotr, Santisteban, Pilar, George, Rani E., Richards, William G., Wong, Kwok-Kin, Locker, Nicolas, Slack, Frank J., Gregory, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234840/
https://www.ncbi.nlm.nih.gov/pubmed/30232453
http://dx.doi.org/10.1038/s41586-018-0538-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234840/
https://www.ncbi.nlm.nih.gov/pubmed/30232453
http://dx.doi.org/10.1038/s41586-018-0538-8

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