Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

Neuronal subtype is largely fixed in the adult mammalian brain. Here, however, we unexpectedly reveal that adult mouse striatal neurons can be reprogrammed into dopaminergic neuron-like cells (iDALs). This in vivo phenotypic reprogramming can be promoted by a stem cell factor (SOX2), three dopaminer...

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Detalles Bibliográficos
Autores principales: Niu, Wenze, Zang, Tong, Wang, Lei-Lei, Zou, Yuhua, Zhang, Chun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234859/
https://www.ncbi.nlm.nih.gov/pubmed/30318292
http://dx.doi.org/10.1016/j.stemcr.2018.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234859/
https://www.ncbi.nlm.nih.gov/pubmed/30318292
http://dx.doi.org/10.1016/j.stemcr.2018.09.004

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