Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites

In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P. falciparum, we identified a loss-of-function mutation in HAD2 (P. falciparum 3D7_1226300 [PF3D7_12...

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Detalles Bibliográficos
Autores principales: Guggisberg, Ann M., Frasse, Philip M., Jezewski, Andrew J., Kafai, Natasha M., Gandhi, Aakash Y., Erlinger, Samuel J., Odom John, Audrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234871/
https://www.ncbi.nlm.nih.gov/pubmed/30425143
http://dx.doi.org/10.1128/mBio.01193-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234871/
https://www.ncbi.nlm.nih.gov/pubmed/30425143
http://dx.doi.org/10.1128/mBio.01193-18

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