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Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress

BACKGROUND: The brain is extensively vascularized, useŝ20% of the body’s oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild hypoxia, aged individuals appear to be even more sensitive. Aging is associated...

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Detalles Bibliográficos
Autores principales: Leiton, Cindy V, Chen, Elyssa, Cutrone, Alissa, Conn, Kristy, Mellanson, Kennelia, Malik, Dania M, Klingener, Michael, Lamm, Ryan, Cutrone, Michael, Petrie, John, Sheikh, Joher, DiBua, Adriana, Cohen, Betsy, Floyd, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234990/
https://www.ncbi.nlm.nih.gov/pubmed/30519596
http://dx.doi.org/10.2147/HP.S173589