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Astrocyte HIF-2α supports learning in a passive avoidance paradigm under hypoxic stress
BACKGROUND: The brain is extensively vascularized, useŝ20% of the body’s oxygen, and is highly sensitive to changes in oxygen. While synaptic plasticity and memory are impaired in healthy individuals by exposure to mild hypoxia, aged individuals appear to be even more sensitive. Aging is associated...
Autores principales: | Leiton, Cindy V, Chen, Elyssa, Cutrone, Alissa, Conn, Kristy, Mellanson, Kennelia, Malik, Dania M, Klingener, Michael, Lamm, Ryan, Cutrone, Michael, Petrie, John, Sheikh, Joher, DiBua, Adriana, Cohen, Betsy, Floyd, Thomas F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234990/ https://www.ncbi.nlm.nih.gov/pubmed/30519596 http://dx.doi.org/10.2147/HP.S173589 |
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