The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial

OBJECTIVES: Dexmedetomidine, a highly selective central α(2)-agonist, undergoes mainly biotransformation in the liver. The pharmacokinetics of dexmedetomidine were significantly affected by hepatic insufficiency. The clearance of dexmedetomidine in patients with severe hepatic failure decreased by 5...

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Detalles Bibliográficos
Autores principales: Song, Jin-Chao, Gao, Hao, Qiu, Hai-Bo, Chen, Qian-Bo, Cai, Mei-Hua, Zhang, Ma-Zhong, Lu, Zhi-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235379/
https://www.ncbi.nlm.nih.gov/pubmed/30427948
http://dx.doi.org/10.1371/journal.pone.0207427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235379/
https://www.ncbi.nlm.nih.gov/pubmed/30427948
http://dx.doi.org/10.1371/journal.pone.0207427

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