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Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neuron...

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Detalles Bibliográficos
Autores principales: Dorman, Daniel B, Jędrzejewska-Szmek, Joanna, Blackwell, Kim T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235562/
https://www.ncbi.nlm.nih.gov/pubmed/30355449
http://dx.doi.org/10.7554/eLife.38588