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Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neuron...

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Autores principales: Dorman, Daniel B, Jędrzejewska-Szmek, Joanna, Blackwell, Kim T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235562/
https://www.ncbi.nlm.nih.gov/pubmed/30355449
http://dx.doi.org/10.7554/eLife.38588
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author Dorman, Daniel B
Jędrzejewska-Szmek, Joanna
Blackwell, Kim T
author_facet Dorman, Daniel B
Jędrzejewska-Szmek, Joanna
Blackwell, Kim T
author_sort Dorman, Daniel B
collection PubMed
description Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition—to enhance the difference in calcium between stimulated and non-stimulated spines. These findings suggest that spine calcium dynamics encode synaptic input patterns and may serve as a signal for both stimulus-specific potentiation and heterosynaptic depression, maintaining balanced activity in a dendritic branch while inducing pattern-specific plasticity.
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spelling pubmed-62355622018-11-16 Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model Dorman, Daniel B Jędrzejewska-Szmek, Joanna Blackwell, Kim T eLife Computational and Systems Biology Synaptic plasticity, which underlies learning and memory, depends on calcium elevation in neurons, but the precise relationship between calcium and spatiotemporal patterns of synaptic inputs is unclear. Here, we develop a biologically realistic computational model of striatal spiny projection neurons with sophisticated calcium dynamics, based on data from rodents of both sexes, to investigate how spatiotemporally clustered and distributed excitatory and inhibitory inputs affect spine calcium. We demonstrate that coordinated excitatory synaptic inputs evoke enhanced calcium elevation specific to stimulated spines, with lower but physiologically relevant calcium elevation in nearby non-stimulated spines. Results further show a novel and important function of inhibition—to enhance the difference in calcium between stimulated and non-stimulated spines. These findings suggest that spine calcium dynamics encode synaptic input patterns and may serve as a signal for both stimulus-specific potentiation and heterosynaptic depression, maintaining balanced activity in a dendritic branch while inducing pattern-specific plasticity. eLife Sciences Publications, Ltd 2018-10-25 /pmc/articles/PMC6235562/ /pubmed/30355449 http://dx.doi.org/10.7554/eLife.38588 Text en © 2018, Dorman et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Dorman, Daniel B
Jędrzejewska-Szmek, Joanna
Blackwell, Kim T
Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title_full Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title_fullStr Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title_full_unstemmed Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title_short Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
title_sort inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235562/
https://www.ncbi.nlm.nih.gov/pubmed/30355449
http://dx.doi.org/10.7554/eLife.38588
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AT blackwellkimt inhibitionenhancesspatiallyspecificcalciumencodingofsynapticinputpatternsinabiologicallyconstrainedmodel