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Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival

The nuclear translocation of endogenous heat shock cognate protein HSPA8 is a requisite for cell survival during oxidative and heat shock stress. Upon these events, cytoplasmic HSPA8 is thought to concentrate within the nucleus and nucleolus. When the situation returns to normal, HSPA8 is released f...

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Detalles Bibliográficos
Autores principales: Wang, Fengjuan, Bonam, Srinivasa Reddy, Schall, Nicolas, Kuhn, Lauriane, Hammann, Philippe, Chaloin, Olivier, Madinier, Jean-Baptiste, Briand, Jean-Paul, Page, Nicolas, Muller, Sylviane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235846/
https://www.ncbi.nlm.nih.gov/pubmed/30429537
http://dx.doi.org/10.1038/s41598-018-34887-6