Cargando…

Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival

The nuclear translocation of endogenous heat shock cognate protein HSPA8 is a requisite for cell survival during oxidative and heat shock stress. Upon these events, cytoplasmic HSPA8 is thought to concentrate within the nucleus and nucleolus. When the situation returns to normal, HSPA8 is released f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Fengjuan, Bonam, Srinivasa Reddy, Schall, Nicolas, Kuhn, Lauriane, Hammann, Philippe, Chaloin, Olivier, Madinier, Jean-Baptiste, Briand, Jean-Paul, Page, Nicolas, Muller, Sylviane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235846/ https://www.ncbi.nlm.nih.gov/pubmed/30429537 http://dx.doi.org/10.1038/s41598-018-34887-6

Ejemplares similares

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

Lysosomes as a therapeutic target
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide
por: Macri, Christophe, et al.
Publicado: (2015)

The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells
por: Page, Nicolas, et al.
Publicado: (2009)

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus
por: Page, Nicolas, et al.
Publicado: (2010)

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2021)

Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases
por: Wang, Fengjuan, et al.
Publicado: (2017)

HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer
por: De Andrade, Warne Pedro, et al.
Publicado: (2020)

Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma
por: Yang, Zongguo, et al.
Publicado: (2015)

Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2020)

ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells
por: Sanchez-Briñas, Alejandra, et al.
Publicado: (2023)

Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
por: Li, Yanhong, et al.
Publicado: (2017)

The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis
por: Bendorius, Mykolas, et al.
Publicado: (2018)

Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans
por: Scieglinska, Dorota, et al.
Publicado: (2014)

The heat shock protein family gene Hspa1l in male mice is dispensable for fertility
por: Wang, Xin, et al.
Publicado: (2020)

Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A
por: Sojka, Damian Robert, et al.
Publicado: (2021)

Upregulation of HSPA1A/HSPA1B/HSPA7 and Downregulation of HSPA9 Were Related to Poor Survival in Colon Cancer
por: Guan, Yufeng, et al.
Publicado: (2021)

The expression of heat shock protein A12B (HSPA12B) in non-Hodgkin’s lymphomas
por: Huang, Yuejiao, et al.
Publicado: (2021)

HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma
por: Min, Xinxu, et al.
Publicado: (2020)

De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease
por: Takahashi, Shinichi, et al.
Publicado: (2017)

Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation
por: Espinoza, Mateo F., et al.
Publicado: (2022)

Differential Targeting of Hsp70 Heat Shock Proteins HSPA6 and HSPA1A with Components of a Protein Disaggregation/Refolding Machine in Differentiated Human Neuronal Cells following Thermal Stress
por: Deane, Catherine A. S., et al.
Publicado: (2017)

HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease
por: Dong, Yeqing, et al.
Publicado: (2022)

Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry
por: Gahoual, Rabah, et al.
Publicado: (2013)

Identification of an exported heat shock protein 70 in Plasmodium falciparum
por: Grover, Manish, et al.
Publicado: (2013)

The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition
por: Nixon, Brett, et al.
Publicado: (2015)

Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization
por: Wang, Lei, et al.
Publicado: (2022)

Diagnostic and Prognostic Risk Assessment of Heat Shock Protein HSPA1B rs2763979 Gene Variant in Asthma
por: Faisal, Salwa, et al.
Publicado: (2022)

Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment
por: Sojka, Damian Robert, et al.
Publicado: (2019)

Heat-Induced Proteotoxic Stress Response in Placenta-Derived Stem Cells (PDSCs) Is Mediated through HSPA1A and HSPA1B with a Potential Higher Role for HSPA1B
por: Alharbi, Bothina Mohammed, et al.
Publicado: (2022)

Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease
por: Texier, Baptiste, et al.
Publicado: (2022)

Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease
por: Rehati, Aliya, et al.
Publicado: (2023)

HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP
por: Gao, Fei, et al.
Publicado: (2022)

Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
por: Sennhauser, Gaby, et al.
Publicado: (2007)

Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia
por: Royer-Bertrand, Beryl, et al.
Publicado: (2015)

Various Anti-HSPA2 Antibodies Yield Different Results in Studies on Cancer-Related Functions of Heat Shock Protein A2
por: Scieglinska, Dorota, et al.
Publicado: (2020)

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A
por: Smulders, Larissa, et al.
Publicado: (2020)

Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein
por: Smulders, Larissa, et al.
Publicado: (2022)

Retracted: HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP
por: Markers, Disease
Publicado: (2023)

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
por: Wisniewska, Magdalena, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7ckh834u1ahinlppdkrh8d5l7u