Cargando…

Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

N(6)-methyladenosine (m(6)A) is the most abundant epigenetic modification in eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian development and disease control. Here we show that conditional knockout of the m(6)A methyltransferase Mettl3 in bone marrow mesenchymal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yunshu, Xie, Liang, Wang, Mengyuan, Xiong, Qiuchan, Guo, Yuchen, Liang, Yu, Li, Jing, Sheng, Rui, Deng, Peng, Wang, Yuan, Zheng, Rixin, Jiang, Yizhou, Ye, Ling, Chen, Qianming, Zhou, Xuedong, Lin, Shuibin, Yuan, Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235890/ https://www.ncbi.nlm.nih.gov/pubmed/30429466 http://dx.doi.org/10.1038/s41467-018-06898-4

Ejemplares similares

Mettl5 mediated 18S rRNA N6-methyladenosine (m(6)A) modification controls stem cell fate determination and neural function
por: Wang, Lu, et al.
Publicado: (2020)

METTL3-Mediated m(6)A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway
por: Liang, Yu, et al.
Publicado: (2021)

METTL3-mediated m(6)A RNA methylation regulates dorsal lingual epithelium homeostasis
por: Xiong, Qiuchan, et al.
Publicado: (2022)

Andrographis paniculata ameliorates estrogen deficiency-related osteoporosis by directing bone marrow mesenchymal stem cell fate
por: Song, Qian, et al.
Publicado: (2023)

METTL3 attenuates proliferative vitreoretinopathy and epithelial‐mesenchymal transition of retinal pigment epithelial cells via wnt/β‐catenin pathway
por: Ma, Xinqi, et al.
Publicado: (2021)

The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression
por: Li, Ding, et al.
Publicado: (2021)

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
por: Wang, Yuan, et al.
Publicado: (2020)

Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
por: Wang, Mengyuan, et al.
Publicado: (2018)

METTL1-mediated m(7)G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development
por: Deng, Yujie, et al.
Publicado: (2020)

METTL3-Mediated m(6)A RNA Modification Regulates Corneal Injury Repair
por: Dai, Yarong, et al.
Publicado: (2021)

METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia
por: Pan, Zhi‐peng, et al.
Publicado: (2021)

Characterization of Nestin, a Selective Marker for Bone Marrow Derived Mesenchymal Stem Cells
por: Xie, Liang, et al.
Publicado: (2015)

Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis
por: Zhou, Tao, et al.
Publicado: (2019)

Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling
por: Li, Li, et al.
Publicado: (2020)

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells
por: Tian, Cheng, et al.
Publicado: (2019)

Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells
por: Kokabu, Shoichiro, et al.
Publicado: (2016)

Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1
por: Huang, Chaoqing, et al.
Publicado: (2022)

MicroRNA‐130a controls bone marrow mesenchymal stem cell differentiation towards the osteoblastic and adipogenic fate
por: Lin, Zhangyuan, et al.
Publicado: (2019)

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis
por: Jafari, Abbas, et al.
Publicado: (2017)

The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation
por: Sun, Yuanxiu, et al.
Publicado: (2021)

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
por: Zhang, Hui, et al.
Publicado: (2022)

APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells
por: LIN, Yuan-Yu, et al.
Publicado: (2020)

Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells
por: Li, Lang, et al.
Publicado: (2018)

METTL1‐m(7)G‐EGFR/EFEMP1 axis promotes the bladder cancer development
por: Ying, Xiaoling, et al.
Publicado: (2021)

Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment
por: Hu, Lifang, et al.
Publicado: (2018)

Applying vibration in early postmenopausal osteoporosis promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells and suppresses postmenopausal osteoporosis progression
por: Li, Huiming, et al.
Publicado: (2019)

Untargeted Metabolomics Reveal the Protective Effect of Bone Marrow Mesenchymal Stem Cell Transplantation Against Ovariectomy-Induced Osteoporosis in Mice
por: Wang, Weizhou, et al.
Publicado: (2022)

A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
por: Liu, Jianzhao, et al.
Publicado: (2013)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis
por: Wang, Cheng, et al.
Publicado: (2016)

Long non-coding RNA XIST promotes osteoporosis through inhibiting bone marrow mesenchymal stem cell differentiation
por: Chen, Xi, et al.
Publicado: (2019)

The m(6)A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment
por: Zhang, Zhaoqiang, et al.
Publicado: (2023)

METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m(6)A/IGF2BPs/Beclin-1 Signal Axis
por: He, Mingyu, et al.
Publicado: (2022)

Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis
por: Yang, Fan, et al.
Publicado: (2019)

METTL3-mediated m(6)A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway
por: Han, Hui, et al.
Publicado: (2021)

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

Alkbh1‐mediated DNA N6‐methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging
por: Cai, Guang‐Ping, et al.
Publicado: (2022)

Mechanosensitive miR-99b mediates the regulatory effect of matrix stiffness on bone marrow mesenchymal stem cell fate both in vitro and in vivo
por: Cao, Bojun, et al.
Publicado: (2023)

The BMP signaling pathway enhances the osteoblastic differentiation of bone marrow mesenchymal stem cells in rats with osteoporosis
por: Zhao, Bin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1l74kpujiapt1apau9nmojhraf